TY - JOUR T1 - Histamine and endotoxin contamination of hay and respirable hay dust. JO - Scandinavian Journal of Work, Environment & Health PY - 1991/8VL - 17 IS - 4 SP - 276 EP - 280 AU - Siegel, P D AU - Olenchock, S A AU - Sorenson, W G AU - Lewis, D M AU - Bledsoe, T A AU - May, J J AU - Pratt, D S M3 - doi: 10.5271/sjweh.1702 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=1702 N2 -

Three distinct samples collected from a barn in which an outbreak of respiratory problems occurred were examined for possible etiologic agents. No causal relationship could be established from the results of this study; however histamine concentrations as high as 0.5 ng/mg for bulk hay (in the absence of measurable creatinine levels) along with 6138.3 endotoxin units/mg of hay were present in the samples. Both endotoxin and histamine could be recovered from respirable hay dust. The authenticity of the histamine found in the hay was evaluated with high-performance liquid chromatography and radioimmunoassay. Histamine release caused by hay extracts was evaluated with the use of leukocytes from the farmer and a referent. Histamine is known to modulate the immune system, but the role of occupational or environmental exposure to histamine in respiratory disease is unknown.

SN - 0355-3140 ER -