%0 Journal Article %T A collaborative study of cancer incidence and mortality among vinyl chloride workers. %A Simonato, Lorenzo %A L'Abbe, K. A. %A Andersen, Aage %A Belli, Stefano %A Comba, Pietro %A Engholm, Göran %A Ferro, Gilles %A Hagmar, Lars %A Langard, S. %A Lundberg, Ingvar %J Scandinavian Journal of Work, Environment & Health %D 1991 %8 June 17 %N 3 %@ 0355-3140 %F Simonato1991 %X

A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).

%R 10.5271/sjweh.1715 %U https://www.sjweh.fi/show_abstract.php?abstract_id=1715 %U https://doi.org/10.5271/sjweh.1715 %P 159-169