PT Journal AU Simonato, L L'Abbe, KA Andersen, A Belli, S Comba, P Engholm, G Ferro, G Hagmar, L Langard, S Lundberg, I TI A collaborative study of cancer incidence and mortality among vinyl chloride workers. SO Scandinavian Journal of Work, Environment & Health PD 6VL PY 1991 BP 159 EP 169 IS 3 DI 10.5271/sjweh.1715 WP https://www.sjweh.fi/show_abstract.php?abstract_id=1715 SN 0355-3140 AB

A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).

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