@Article{Takeuchi1988, author = "Takeuchi, T. and Takeya, M. and Imanishi, H.", title = "Ultrastructural changes in peripheral nerves of the fingers of three vibration-exposed persons with Raynaud's phenomenon.", journal = "Scandinavian Journal of Work, Environment & Health", year = "1988", month = "Feb", day = "14", number = "1", pages = "31--35", abstract = "
A finger biopsy was performed on three patients with vibration-induced white finger (VWF), and the specimens were examined by electron microscopy for peripheral nerve changes. A characteristic neuropathy with perineurial fibrosis was revealed which was often accompanied by a thickened perineurium with a lamellar structure resembling onion skin. This peculiar fibrosis consisted of elongated cytoplasmic projections of perineurial cells or fibroblasts and a greatly increased amount of collagen which occasionally contained fibrous long-spacing collagen. In the endoneurium, a decrease in the number of nerve fibers and a marked increase in collagen with fibroblasts were noted. Myelinated axons became smaller, and this occurrence suggested incomplete regeneration. The pathological changes were presumably the result of the long-term clinical course of VWF.
", issn = "0355-3140", doi = "10.5271/sjweh.1953", url = "https://www.sjweh.fi/show_abstract.php?abstract_id=1953", url = "https://doi.org/10.5271/sjweh.1953" }