PT Journal AU Nielsen, J Sango, C Winroth, G Hallberg, T Skerfving, S TI Systemic reactions associated with polyisocyanate exposure. SO Scandinavian Journal of Work, Environment & Health PD 2VL PY 1985 BP 51 EP 54 IS 1 DI 10.5271/sjweh.2253 WP https://www.sjweh.fi/show_abstract.php?abstract_id=2253 SN 0355-3140 AB

A spray-painter suffered attacks of chills, fever, general malaise, dyspnea and wheezing, headache, arthralgia, and leucocytosis a few hours after exposure to aerosols of varnishes containing two different polyisocyanates based upon monomers of hexamethylene or toluene diisocyanate. Immunologic studies revealed an increase in the serum immunoglobulin G level, but no specific antibodies against isocyanates conjugated to human serum albumin. The polyisocyanate level in the workroom air was high [a time-weighted average of 4.2 mg/m3, corresponding to 17 mumol NCO (isocyanate groups)/m3], the toluene diisocyanate monomer level being much lower (a time-weighted average of 0.03 mg/m3, corresponding to 0.3 mumol NCO/m3).

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