TY - JOUR T1 - Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case–control studies JO - Scandinavian Journal of Work, Environment & Health PY - 2015/9VL - 41 IS - 5 SP - 467 EP - 477 AU - Taeger, Dirk AU - Pesch, Beate AU - Kendzia, Benjamin AU - Behrens, Thomas AU - Jöckel, Karl-Heinz AU - Dahmann, Dirk AU - Siemiatycki, Jack AU - Kromhout, Hans AU - Vermeulen, Roel AU - Peters, Susan AU - Olsson, Ann AU - Brüske, Irene AU - Wichmann, Heinz-Erich AU - Stücker, Isabelle AU - Guida, Florence AU - Tardón, Adonina AU - Merletti, Franco AU - Mirabelli, Dario AU - Richiardi, Lorenzo AU - Pohlabeln, Hermann AU - Ahrens, Wolfgang AU - Landi, Maria Teresa AU - Caporaso, Neil AU - Pesatori, Angela Cecilia AU - Mukeriya, Anush AU - Szeszenia-Dabrowska, Neonila AU - Lissowska, Jolanta AU - Gustavsson, Per AU - Field, John AU - Marcus, Michael W AU - Fabianova, Eleonora AU - ’t Mannetje, Andrea AU - Pearce, Neil AU - Rudnai, Peter AU - Bencko, Vladimir AU - Janout, Vladimir AU - Dumitru, ­Rodica Stanescu AU - Foretova, Lenka AU - Forastiere, Francesco AU - McLaughlin, John AU - Demers, Paul AU - Bueno-de-Mesquita, Bas AU - Schüz, Joachim AU - Straif, Kurt AU - Brüning, Thomas M3 - doi: 10.5271/sjweh.3513 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=3513 KW - cancer KW - case–control study KW - coal miner KW - coal mining KW - histological subtype KW - lung cancer KW - lung cancer KW - mining KW - ore miner KW - ore mining KW - pooled analysis KW - population-based study KW - quarrymen KW - risk estimate KW - smoking N2 - '

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OBJECTIVES ': 'Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen.

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METHODS ': 'We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations.

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RESULTS ': 'Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure.

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CONCLUSIONS ': 'This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

SN - 0355-3140 ER -