TY - JOUR T1 - Prostate cancer risk among French farmers in the AGRICAN cohort JO - Scandinavian Journal of Work, Environment & Health PY - 2016/3VL - 42 IS - 2 SP - 144 EP - 152 AU - Lemarchand, Clémentine AU - Tual, Séverine AU - Boulanger, Mathilde AU - Levêque-Morlais, Noémie AU - Perrier, Stéphanie AU - Clin, Bénédicte AU - Guizard, Anne-Valérie AU - Velten, Michel AU - Rigaud, Emma AU - Baldi, Isabelle AU - Lebailly, Pierre M3 - doi: 10.5271/sjweh.3552 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=3552 KW - AGRICAN KW - agriculture KW - cancer KW - cohort KW - cohort study KW - exposure KW - farmer KW - farming KW - France KW - French farmer KW - pesticide KW - prostate KW - prostate cancer N2 - '

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OBJECTIVES ': 'Prostate cancer is one of the most frequent cancers among men worldwide. Its etiology is largely unknown, but an increased risk has been repeatedly observed among farmers. Our aim was to identify occupational risk factors for prostate cancer among farmers in the prospective cohort study AGRICAN.

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METHODS ': 'Data on lifetime agricultural exposures (type of crops, livestock and tasks including pesticide use, re-entry and harvesting) were collected from the enrolment questionnaire. During the period from enrolment (2005–2007) to 31 December 2009, 1672 incident prostate cancers were identified. Hazard ratios (HR) were estimated using Cox regression analysis.

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RESULTS ': 'We found an increased risk for cattle breeders using insecticides [HR 1.20, 95% confidence interval (95% CI) 1.01–1.42] with a significant dose–response relationship with number of cattle treated (P for trend 0.01). A dose–response relationship was also observed with the number of hogs (P for trend 0.06). We found an excess of prostate cancer risk among people involved in grassland activities, mainly in haymaking (HR 1.18, 95% CI 1.02–1.36). Pesticide use and harvesting among fruit growers were associated with an elevated prostate cancer risk, with a two-fold increased risk for the largest area. For potato and tobacco producers, an elevated prostate cancer risk was observed for almost all tasks, suggesting a link with pesticide exposure since all of them potentially involved pesticide exposure.

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CONCLUSIONS ': 'Our analysis suggests that the risk of prostate cancer is increased in several farming activities (cattle and hog breeding, grassland and fruit-growing) and for some tasks including pesticide use.

SN - 0355-3140 ER -