%0 Journal Article %T Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study %A Deltour, Isabelle %A Schlehofer, Brigitte %A Massardier-Pilonchéry, Amélie %A Schlaefer, Klaus %A Armstrong, Bruce %A Giles, Graham G. %A Siemiatycki, Jack %A Parent, Marie-Elise %A Krewski, Daniel %A McBride, Mary %A Johansen, Christoffer %A Auvinen, Anssi %A Salminen, Tiina %A Hours, Martine %A Montestrucq, Lucile %A Blettner, Maria %A Berg-Beckhoff, Gabriele %A Sadetzki, Siegal %A Chetrit, Angela %A Lagorio, Susanna %A Iavarone, Ivano %A Yamaguchi, Naohito %A Takebayashi, Toru %A Woodward, Alistair %A Cook, Angus %A Tynes, Tore %A Klaeboe, Lars %A Feychting, Maria %A Lönn, Stefan %A Fleming, Sarah %A Swerdlow, Anthony J. %A Schoemaker, Minouk J. %A Moissonnier, Monika %A Kesminiene, Ausrele %A Cardis, Elisabeth %A Schüz, Joachim %A 10.5271/sjweh.3781, INTERPHONE Study GroupM3 -. doi: %J Scandinavian Journal of Work, Environment & Health %D 2019 %8 March 45 %N 2 %@ 0355-3140 %F Deltour2019 %X '

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OBJECTIVE ': 'Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure.

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METHODS ': 'Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets.

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RESULTS ': 'The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise.

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CONCLUSION ': 'The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

%K acoustic neuroma %K case‒control study %K epidemiology %K exposure %K international %K INTERPHONE %K loud noise %K noise %K noise exposure %K vestibular schwannoma %U https://www.sjweh.fi/show_abstract.php?abstract_id=3781 %P 183-193