TY - JOUR T1 - Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study JO - Scandinavian Journal of Work, Environment & Health PY - 2019/3VL - 45 IS - 2 SP - 183 EP - 193 AU - Deltour, Isabelle AU - Schlehofer, Brigitte AU - Massardier-Pilonchéry, Amélie AU - Schlaefer, Klaus AU - Armstrong, Bruce AU - Giles, Graham G AU - Siemiatycki, Jack AU - Parent, Marie-Elise AU - Krewski, Daniel AU - McBride, Mary AU - Johansen, Christoffer AU - Auvinen, Anssi AU - Salminen, Tiina AU - Hours, Martine AU - Montestrucq, Lucile AU - Blettner, Maria AU - Berg-Beckhoff, Gabriele AU - Sadetzki, Siegal AU - Chetrit, Angela AU - Lagorio, Susanna AU - Iavarone, Ivano AU - Yamaguchi, Naohito AU - Takebayashi, Toru AU - Woodward, Alistair AU - Cook, Angus AU - Tynes, Tore AU - Klaeboe, Lars AU - Feychting, Maria AU - Lönn, Stefan AU - Fleming, Sarah AU - Swerdlow, Anthony J AU - Schoemaker, Minouk J AU - Moissonnier, Monika AU - Kesminiene, Ausrele AU - Cardis, Elisabeth AU - Schüz, Joachim AU - INTERPHONE Study GroupM3 - doi: 10.5271/sjweh.3781 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=3781 KW - acoustic neuroma KW - case‒control study KW - epidemiology KW - exposure KW - international KW - INTERPHONE KW - loud noise KW - noise KW - noise exposure KW - vestibular schwannoma N2 - '

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OBJECTIVE ': 'Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure.

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METHODS ': 'Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets.

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RESULTS ': 'The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise.

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CONCLUSION ': 'The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

SN - 0355-3140 ER -