%0 Journal Article %T Exposure-response relationships for hexahydrophthalic and methylhexahydrophthalic anhydrides with total plasma protein adducts as biomarkers %A Rosqvist, Seema %A Nielsen, Jorn %A Welinder, Hans %A Rylander, Lars %A Lindh, Christian H. %A Jönsson, Bo AG %J Scandinavian Journal of Work, Environment & Health %D 2003 %8 August 29 %N 4 %@ 0355-3140 %F Rosqvist2003 %X '

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OBJECTIVES ': 'This study investigated the exposure-response relationships of hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) and evaluated the applicability of the total plasma protein adducts (TPPA) of these anhydrides as biomarkers of exposure and risk.

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METHODS ': 'In a cross-sectional study of 139 workers in a plant manufacturing electrical capacitors, the long-term exposure to HHPA and MHHPA was assessed through the quantification of TPPA using gas chromatography-mass spectrometry. Smoking and medical histories were obtained through questionnaires. Work-related symptoms of the eyes and airways were recorded. Specific immunoglobulin (Ig) E (radioallergosorbent test) and IgG (enzyme-linked immunosorbent assay) were determined in serum.

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RESULTS ': 'The mean level of the TPPA of HHPA was 840 fmol/ml and that of the TPPA of MHHPA was 1700 fmol/ml. There was no correlation between the TPPA of HHPA and the TPPA of MHHPA. Of all the workers, 19% were found to be positive for specific IgE and 17-19% for IgG. Positive associations were observed between HHPA exposure and specific IgE and IgG, respectively, and between MHHPA exposure and specific IgG. Regarding work-related symptoms, 27% of the workers had symptoms from the nose, 21% had symptoms from the eyes, 11% had symptoms from the lower airways, and 8% had nose bleeding. There were significant exposure-response relationships for symptoms of the eyes and nose for HHPA exposure.

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CONCLUSIONS ': 'The results show that there is an exposure-response relationship for HHPA both with specific antibodies and with work-related symptoms and down to adduct levels of 40 fmol/ml plasma. In addition, the results elucidate the potential power of TPPA as a relevant index of exposure and risk.

%K biomarker %K exposure-response relationship %K hexahydrophthalic anhydride %K methylhexahydrophthalic anhydride %K phthalic anhydride %K protein adduct %K total plasma protein adduct %R 10.5271/sjweh.734 %U https://www.sjweh.fi/show_abstract.php?abstract_id=734 %U https://doi.org/10.5271/sjweh.734 %P 297-303