ORIGINAL ARTICLE
Disappearance of carbon monoxide from the blood – comparison of the one-exponential and two-exponential elimination models for rat
Publication date: 1981-09-01
Corresponding author
Institute of Occupational Health, SF-00290 Helsinki, Finland.
Scand J Work Environ Health 1981;7(3):233-236
KEYWORDS
ratcarbon monoxidebloodcarboxyhemoglobintwo-exponential elimination modelone-exponential elimination modelelimination model
ABSTRACT
The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.
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| eISSN: | 1795-990X |
| ISSN: | 0355-3140 |
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