ORIGINAL ARTICLE
Mortality of workers employed at organochlorine pesticide manufacturing plants--an update.
 
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Publication date: 1992-06-01
 
 
Corresponding author
Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
 
 
Scand J Work Environ Health 1992;18(3):155-161
 
ABSTRACT
A previous mortality study among four organochlorine pesticide manufacturers was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and dichlorodiphenyltrichloroethane. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (5 observed, standardized mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumors of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumors, and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer.
eISSN:1795-990X
ISSN:0355-3140
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