TY - JOUR T1 - Influence of pesticides on male fertility JO - Scandinavian Journal of Work, Environment & Health PY - 2007/2VL - 33 IS - 1 SP - 13 EP - 28 AU - Bretveld, Reini AU - Brouwers, Marijn AU - Ebisch, Inge AU - Roeleveld, Nel M3 - doi: 10.5271/sjweh.1060 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=1060 KW - endocrine disrupting chemical KW - hormone regulation KW - male fertility KW - overview KW - pesticide KW - review KW - sperm quality KW - time to pregnancy N2 -

Several studies have shown a decline in human semen quality and increased risks of male subfertility. This paper provides an overview of the mechanisms of pesticide-induced reproductive toxicity and the effects on male fertility since exposure to pesticides may be one of the causes of these disorders. Pesticides may directly damage spermato­zoa, alter Sertoli cell or Leydig cell function, or disrupt the endocrine function in any stage of hormonal regulation (hormone synthesis, release, storage, transport, and clearance; receptor recognition and binding; thyroid function; and the central nervous system). These mechanisms are described with respect to the effects of pesticide exposure in vitro and in vivo. In epidemiologic studies, effects on sperm quality and time to pregnancy are reviewed. Clear effects on male fertility have been demonstrated for some pesticides [eg, dibromochloropropane, ethylene dibromide]. But results from more recent studies are inconsistent, and no uniform conclusion can be drawn about the effects of pesticides on male reproduction.

SN - 0355-3140 ER -