TY - JOUR T1 - Chelated lead and bone lead. JO - Scandinavian Journal of Work, Environment & Health PY - 1992/4VL - 18 IS - 2 SP - 113 EP - 119 AU - Tell, I AU - Somervaille, L J AU - Nilsson, U AU - Bensryd, I AU - Schutz, A AU - Chettle, DR AU - Scott, M C AU - Skerfving, Staffan M3 - doi: 10.5271/sjweh.1603 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=1603 N2 -

In this study a close correlation [correlation coefficient (r) = 0.86, P less than 0.001] was found between the blood lead level of 20 lead workers and their urinary excretion of lead for 24 h after intravenous infusion with 1 g of the chelating agent calcium disodium edetate. In addition, there were significant associations between lead levels in different bones (tibia/calcaneus: r = 0.93, P less than 0.001; tibia/phalanx: r = 0.67, P less than 0.002; calcaneus/phalanx: r = 0.80, P less than 0.001), as measured by in vivo X-ray fluorescence. Chelation produced no significant change in the lead level in either tibia or calcaneus. There was a significant correlation between chelated lead and bone lead (eg, for calcaneus, r = 0.62) in currently exposed workers. However, there was no significant relationship when a retired worker and an inactive worker were included (r = 0.14). It was concluded that chelatable lead mainly reflects the blood and soft-tissue lead pool, which is only partly dependent upon the skeletal lead content that comprises the biggest share of the total body burden.

SN - 0355-3140 ER -