@Article{Selden1989, author = "Selden, A. I. and Belin, Lars and Wass, Urban", title = "Isocyanate exposure and hypersensitivity pneumonitis--report of a probable case and prevalence of specific immunoglobulin G antibodies among exposed individuals.", journal = "Scandinavian Journal of Work, Environment & Health", year = "1989", month = "Jun", day = "15", number = "3", pages = "234--237", abstract = "
A car painter experienced three episodes of a hypersensitivity pneumonitis-like disease after exposure to two-component acrylic lacquers with hexamethylene diisocyanate (HDI) as the curing agent. High titers of HDI-specific immunoglobulin (Ig) G antibodies were found in the patient's serum by means of enzyme-linked immunosorbent assay (ELISA). In the ELISA, 5 to 10% of the sera from 455 isocyanate-exposed but asymptomatic workers were positive, depending on the criterion used for a positive test, whereas 0% of the sera from 157 unexposed referents was found to be positive. Among 10 subjects with isocyanate-induced asthma and isocyanate-specific IgE antibodies, 50% had specific IgG. It was concluded that the presence of isocyanate-specific IgG antibodies in serum is correlated with isocyanate exposure rather than with symptoms of isocyanate-induced disease.
", issn = "0355-3140", doi = "10.5271/sjweh.1857", url = "https://www.sjweh.fi/show_abstract.php?abstract_id=1857", url = "https://doi.org/10.5271/sjweh.1857" }