PT Journal AU Ladefoged, O Perbellini, L TI Acetone-induced changes in the toxicokinetics of 2,5-hexanedione in rabbits. SO Scandinavian Journal of Work, Environment & Health PD 12VL PY 1986 BP 627 EP 629 IS 6 DI 10.5271/sjweh.2092 WP https://www.sjweh.fi/show_abstract.php?abstract_id=2092 SN 0355-3140 AB

Male rabbits were intravenously injected with 2,5-hexanedione or 2,5-hexanedione plus acetone. A toxicokinetic analysis showed that a two-compartment model satisfactorily described the kinetics of 2,5-hexanedione in rabbits. Simultaneous dosing with acetone altered the toxicokinetic model which best described the plasma concentration versus time data. The model-independent parameter body clearance, calculated according to the trapezoidal rule, showed a decrease in the body clearance of 2,5-hexanedione in rabbits simultaneously injected with acetone. The results suggest that toxicokinetic interference may partly explain the neurotoxic potentiation of that which occurs in 2,5-hexanedione-induced axonopathy as a response to simultaneous exposure to acetone.

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