TY - JOUR T1 - Acetone-induced changes in the toxicokinetics of 2,5-hexanedione in rabbits. JO - Scandinavian Journal of Work, Environment & Health PY - 1986/12VL - 12 IS - 6 SP - 627 EP - 629 AU - Ladefoged, O AU - Perbellini, L M3 - doi: 10.5271/sjweh.2092 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=2092 N2 -

Male rabbits were intravenously injected with 2,5-hexanedione or 2,5-hexanedione plus acetone. A toxicokinetic analysis showed that a two-compartment model satisfactorily described the kinetics of 2,5-hexanedione in rabbits. Simultaneous dosing with acetone altered the toxicokinetic model which best described the plasma concentration versus time data. The model-independent parameter body clearance, calculated according to the trapezoidal rule, showed a decrease in the body clearance of 2,5-hexanedione in rabbits simultaneously injected with acetone. The results suggest that toxicokinetic interference may partly explain the neurotoxic potentiation of that which occurs in 2,5-hexanedione-induced axonopathy as a response to simultaneous exposure to acetone.

SN - 0355-3140 ER -