PT Journal AU Wigaeus, E Löf, A Nordqvist, M TI Distribution and elimination of 2-[14C]-acetone in mice after inhalation exposure. SO Scandinavian Journal of Work, Environment & Health PD 6VL PY 1982 BP 121 EP 128 IS 2 DI 10.5271/sjweh.2486 WP https://www.sjweh.fi/show_abstract.php?abstract_id=2486 DE 2-[14C]-acetone; acetone; distribution; elimination; expiry date; inhalation exposure; metabolite; mouse; tissue concentration SN 0355-3140 AB

This study was undertaken to determine the tissue distribution and elimination of acetone and its metabolic radioactive fragments in mice after exposure to about 1,200 mg/m3 (500 ppm) of 2-[14C]-acetone vapor. The tissue concentrations of acetone seemed to reach steady state plateaus within 6 h of exposure. In the adipose tissue the maximal concentration was about one-third of that in the highly perfused nonadipose tissues, in which acetone was rather evenly distributed. The contents of radioactivity also reached a plateau within 6 h of exposure in all tissues except the liver and brown adipose tissue. In these tissues the radioactivity increased during exposures up to 24 h. Prolonging the exposure time from 6 h to 6 h/d for three and five consecutive days gave no or only a small additional accumulation of radioactivity in all tissues except adipose tissue. The half-times of acetone after 6 h of exposure were between 2 and 5 h in all tissues. Almost equal amounts of acetone were excreted via the lungs unmetabolized or metabolized to carbon dioxide. In all tissues endogenous levels of acetone were reached within 24 h after exposure. Thus, acetone did not accumulate after prolonged or repeated exposure to concentrations of 1,200 mg/m3.

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