TY - JOUR T1 - Relationship between clinical and electrophysiological findings and indicators of heavy exposure to 2,3,7,8-tetrachlorodibenzo-dioxin. JO - Scandinavian Journal of Work, Environment & Health PY - 1981/12VL - 7 IS - 4 SP - 257 EP - 262 AU - Filippini, Graziella AU - Bordo, Bianca AU - Crenna, Paolo AU - Massetto, Nicoletta AU - Musicco, Massimo AU - Boeri, Renato M3 - doi: 10.5271/sjweh.2553 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=2553 KW - 2,3,7,8-tetrachlorodibenzo-dioxin KW - chloracne KW - clinical finding KW - dioxin KW - electrophysiological finding KW - environmental pollutant KW - heavy exposure KW - liver KW - liver damage KW - neuropathy KW - peripheral neuropathy KW - raised serum hepatic enzyme level KW - serum hepatic enzyme KW - serum hepatic enzyme level N2 -

In this study the prevalence rate of peripheral neuropathy in a population living in an area polluted with 2,3,7,8-tetrachlorodibenzo-dioxin (dioxin-TCDD) was determined. Of the 723 subjects invited to the first screening in 1977, 470 (65%) attended. At the second screening in 1978, of the 710 invited subjects, 319 (45%) attended. Prevalence rate ratios for peripheral neuropathy and the associated 95% confidence limits were calculated for subgroups determined by the presence of (i) predisposing factors to neuropathy (alcoholism, diabetes, occupational exposure to neurotoxic agents, etc) or (ii) conditions thought to result from exposure to dioxin-TCDD such as chloracne or abnormal serum hepatic enzyme levels. The prevalence rate of peripheral neuropathy among those subjects with predisposing factors and among those with chloracne or abnormal serum hepatic enzyme levels was nearly three times greater than among those without these manifestations. The results derived from this study may be useful qualitative pointers for identifying subjects at risk in the neurological follow-up.

SN - 0355-3140 ER -