TY - JOUR T1 - Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs. JO - Scandinavian Journal of Work, Environment & Health PY - 1980/12VL - 6 IS - 4 SP - 299 EP - 301 AU - Norppa, Hannu AU - Sorsa, Marja AU - Vainio, Harri AU - Gröhn, Pentti AU - Heinonen, Erkki AU - Holsti, Lars AU - Nordman, Eeva M3 - doi: 10.5271/sjweh.2605 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=2605 KW - carcinogen KW - chemotherapeutic drug KW - chromosome damage KW - cytostatic drug KW - lymphocyte KW - mutagen KW - nurse KW - occupational exposure KW - sister chromatid exchange frequency N2 -

In oncology units, personnel handling chemotherapeutic drugs may occasionally be exposed to small amounts of genotoxic agents. This exposure was obviously the cause of the increased frequencies of sister chromatid exchange (SCE) observed in nurses in daily contact with cytostatics (N = 20, mean SCEs/cell +/- SE 9.4 +/- 0.3) as compared to a group of office workers (N = 10, mean SCEs/cell 8.1 +/- 0.3). The oncology nurses also had a higher SCE frequency than other hospital nurses (N = 10, mean SCEs/cell 8.7 +/- 0.2), but this difference was not statistically significant. The SCEs of patients under chemotherapy were about five times higher (mean SCEs/cell 36.8 +/- 0.6) than those of healthy subjects.

SN - 0355-3140 ER -