PT Journal AU Ikeda, M Hirayama, T TI Possible metabolic interaction of styrene with organic solvents. SO Scandinavian Journal of Work, Environment & Health PD VL PY 1978 BP 41 EP 46 IS 2 DI 10.5271/sjweh.2737 WP https://www.sjweh.fi/show_abstract.php?abstract_id=2737 DE coexposure; metabolic interaction; organic solvent; styrene; toluene; trichloroethylene SN 0355-3140 AB

Excretion of metabolites of styrene (dose: 2.2 mmol/kg i.p.) in 24-h urine was suppressed when rats were coinjected intraperitoneally with either toluene or trichloroethylene (dose: 2.2--11.0 mmol/kg) in addition to styrene, while a coinjection of n-hexane, ethyl acetate, methylchloroform, or acetone at an equimolar dose was ineffective in all cases. Suppressive effects of toluene and trichloroethylene were further confirmed by 6-h vapor exposure to (a) 0 to 1,300 ppm of toluene in addition to 150--170 ppm of styrene and (b) 0 to 4,000 ppm of trichloroethylene together with 100 or 150 ppm of styrene. The relationship between the amounts of three metabolites (i.e., phenylglyoxylic, mandelic and hippuric acids) in urine and styrene concentration in air was also determined.

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