PT Journal AU Ji, B Gao, Y Shu, X Yang, G Yu, K Xue, S Li, H Liao, LM Blair, A Rothman, N Zheng, W Chow, W TI Nightshift work job exposure matrices and urinary 6-sulfatoxymelatonin levels among healthy Chinese women SO Scandinavian Journal of Work, Environment & Health PD 11VL PY 2012 BP 553 EP 559 IS 6 DI 10.5271/sjweh.3322 WP https://www.sjweh.fi/show_abstract.php?abstract_id=3322 DE aMT6s; cancer; China; job exposure matrix; melatonin; night shift; nighttime work; shift work; urinary 6-sulfatoxymelatonin; urine sample; woman SN 0355-3140 AB '

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OBJECTIVE ': 'Six-sulfatoxymelatonin (aMT6s) is a primary urinary metabolite of melatonin. We examined the association between aMT6s levels and shift work estimated by a job exposure matrix (JEM) among healthy participants of the Shanghai Women’s Health Study.

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METHODS ': 'Creatinine-adjusted aMT6s levels were measured in the urine samples of 300 women and related to JEM shift work categories.

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RESULTS ': 'Adjusted geometric means of aMT6s levels from urine samples collected before 08:00 hours were lower among persons holding nighttime shift work jobs. The adjusted aMT6s levels (ng/mg creatinine) were 8.36 [95% confidence intervals (95% CI) 4.47–15.6], 6.37 (95% CI 3.53–11.5), 6.20 (95% CI 3.33–11.5), 3.81 (95% CI 2.02–7.19), and 3.70 (95% CI 1.92–7.11) from the lowest (never held a shift work job) to the highest (current job likely involved all-night shift work) shift work JEM scores (P=0.05).

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CONCLUSION ': 'Our results indicate that nightshift work JEM scores were significantly and inversely associated with aMT6s levels in early morning spot urine samples collected between 07:00–08:00 hours.

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