@Article{Tenkanen1998, author = "Tenkanen, Leena and Sjöblom, Tom and Härmä, Mikko", title = "Joint effect of shift work and adverse life-style factors on the risk of coronary heart disease", journal = "Scandinavian Journal of Work, Environment & Health", year = "1998", month = "Oct", day = "24", number = "5", pages = "351--357", keywords = "circadian rhythm; interaction; obesity; physical activity; smoking; thrombosis", abstract = "'
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OBJECTIVES ': 'The joint effect of shift work and certain adverse life-style factors on coronary heart disease (CHD) was studied.'
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METHODS ': 'Base-line measurements were obtained for a 6-year follow-up of an industrially employed cohort (N=1806), whose shiftwork status was recorded from a questionnaire filled out by a sample of the cohort. The CHD end points (codes 410-414 of the 9th revision of the International Classification of Diseases) were obtained from official Finnish registers. In order that the joint effects of shift work and life-style factors on the risk of CHD could be studied, dichotomized variables and their combinations as a dummy variable system in Cox's proportional hazards models were used.'
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RESULTS ': 'The relative risks were 1, 1.6 [95% confidence interval (95% CI) 1.1-2.5], 1.3 (95% CI 0.9-2.1), and 2.7 (95% CI 1.8-4.1) for the following combinations of shift work (SW) and smoking (SM): SW-&SM-, SW-&SM+, SW+&SM-, and SW+&SM+, respectively; and the corresponding figures for shift work and obesity (BMI ³28 kg/m2) were 1, 1.2 (95% CI 0.8-1.9), 1.3 (95% CI 0.9-1.9), and 2.3 (95% CI 1.5-3.6), respectively. In both cases the effect was at least multiplicative. For the shift workers the relative risk for CHD rose gradually with increasing numbers of adverse life-style factors, but for the day workers there was no clear dose-response pattern.'
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CONCLUSION ': 'Shift work seems to trigger the effect of other, lifestyle-related risk factors of CHD and therefore calls for active prevention among shift workers.
", issn = "0355-3140", doi = "10.5271/sjweh.355", url = "https://www.sjweh.fi/show_abstract.php?abstract_id=355", url = "https://doi.org/10.5271/sjweh.355" }