%0 Journal Article %T Occupational and recreational physical activity and Parkinson’s disease in Denmark %A Shih, I-Fan %A Starhof, Charlotte %A Lassen, Christina Funch %A Hansen, Johnni %A Liew, Zeyan %A Ritz, Beate %J Scandinavian Journal of Work, Environment & Health %D 2017 %8 May 43 %N 3 %@ 0355-3140 %F Shih2017 %X '

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OBJECTIVES ': 'This study aimed to examine whether occupational and physical activity (PA) at different ages contribute to Parkinson’s disease (PD) risk in a large population-based case-control study in Denmark.

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METHODS ': 'We identified 1828 PD patients from the Danish National Hospital Register and recruited 1909 gender and year of birth matched controls from the Danish Central Population Register. Occupational and leisure-time PA were determined from a job exposure matrix based on occupational history and self-reported leisure-time information.

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RESULTS ': 'No association was found for occupational PA alone in men, but higher leisure-time PA (≥5 hours/week of strenuous activities) in young adulthood (15–25 years) was associated with a lower PD risk (adjusted odds ratio (ORadj) 0.75, 95% confidence interval (95% CI) 0.62–0.90); men who engaged in high occupational and high leisure-time PA in young adulthood had the lowest PD risk (ORadj 0.58, 95% CI 0.41–0.81). Among women, inverse associations were found for occupation PA before age 50 (highest vs lowest, ORadj 0.75, 95% CI 0.55–1.06) and strenuous leisure-time PA after age 50 (ORadj 0.65, 95% CI 0.87–0.99); no clear pattern was seen for leisure and occupational PA combined.

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CONCLUSIONS ': 'We observed gender-specific inverse associations between occupational and leisure-time PA and PD risk; however, we cannot preclude reverse causation especially in older ages since PD has a long prodromal stage that might lead to a reduction of PA years before motor symptom onset and PD diagnosis.

%K Denmark %K exercise %K job exposure matrix %K leisure-time physical activity %K occupational physical activity %K Parkinson’s disease %K physical activity %K recreational physical activity %K work %R 10.5271/sjweh.3633 %U https://www.sjweh.fi/show_abstract.php?abstract_id=3633 %U https://doi.org/10.5271/sjweh.3633 %P 210-216