TY - JOUR T1 - Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study JO - Scandinavian Journal of Work, Environment & Health PY - 2018/9VL - 44 IS - 5 SP - 539 EP - 546 AU - Hjortebjerg, Dorrit AU - Nybo Andersen, Anne-Marie AU - Ketzel, Matthias AU - Raaschou-Nielsen, Ole AU - Sørensen, Mette M3 - doi: 10.5271/sjweh.3724 UR - https://www.sjweh.fi/show_abstract.php?abstract_id=3724 KW - air pollution KW - cohort study KW - exposure KW - febrile seizure KW - noise KW - traffic noise N2 - '

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OBJECTIVES ': 'Exposure to traffic noise and air pollution is suspected to increase susceptibility to viral infections – the main triggering factor for febrile seizures. No studies have examined these two exposures in relation to febrile seizures. We aimed to investigate whether exposure to road traffic noise and air pollution are associated with risk of febrile seizures in childhood.

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METHODS ': 'From our study base of 51 465 singletons from a national birth cohort, we identified 2175 cases with febrile seizures using a nationwide registry. Residential address history from conception to six years of age were found in national registers, and road traffic noise (Lden) and air pollution (NO2) were modeled for all addresses. Analyses were done using Cox proportional hazard model with adjustment for potential confounders, including mutual exposure adjustment.

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RESULTS ': 'An interquartile range (IQR) increase in childhood exposure to road traffic noise and air pollution was associated with an 11% [incidence rate ratio (IRR) 1.11, 95% confidence interval (CI) 1.04–1.19) and 5% (IRR 1.05, 95% CI 1.02–1.07) higher risk for febrile seizures, respectively, after adjustment for potential confounders. Weaker tendencies were seen for pregnancy exposure. In models with mutual exposure adjustment, the estimates were slightly lower, with IRR of 1.08 (95% CI 1.00–1.16) and 1.03 (95% CI 0.99–1.06) per IQR increase in childhood exposure to road traffic noise and air pollution, respectively.

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CONCLUSIONS ': 'This study suggests that residential exposure to road traffic noise and air pollution is associated with higher risk for febrile seizures.

SN - 0355-3140 ER -