PT Journal AU Sjögren, B Wang, Z Larsson, B Larsson, K Larsson, PH Westerholm, P TI Increase in interleukin-6 and fibrinogen in peripheral blood after swine dust inhalation SO Scandinavian Journal of Work, Environment & Health PD 2VL PY 1999 BP 39 EP 41 IS 1 DI 10.5271/sjweh.381 WP https://www.sjweh.fi/show_abstract.php?abstract_id=381 DE endotoxin SN 0355-3140 AB '

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OBJECTIVES ': 'The inhalation of dust from swine confinement buildings causes inflammatory responses in the airways with a rise of interleukin-6 (IL-6). The purpose of this study was to confirm the increase in serum IL-6 after inhalation of swine dust and investigate a possible increase in plasma fibrinogen.'

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METHODS ': 'Eight healthy nonsmoking volunteers inhaled dust for 4 hours inside a swine confinement building. Inhalable dust and endotoxin were sampled. The concentrations of IL-6 and fibrinogen were determined in serum and plasma.'

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RESULTS ': 'The study showed a clear increase in the concentrations of IL-6 and fibrinogen after exposure.'

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CONCLUSION ': 'As fibrinogen is an important risk factor for ischemic heart disease, the increased concentration of fibrinogen among persons exposed to swine dust may increase the risk for this disease.

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