@Article{Ellingsen2000, author = "Ellingsen, Dag G. and Efskind, Jon and Berg, K. J. and Gaarder, Per I. and Thomassen, Yngvar", title = "Renal and immunologic markers for chloralkali workers with low exposure to mercury vapor", journal = "Scandinavian Journal of Work, Environment & Health", year = "2000", month = "Oct", day = "26", number = "5", pages = "427--435", keywords = "autoantibodies to myeloperoxidase; urinary N-acetyl-beta-D-glucosaminidase", abstract = "'
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OBJECTIVES ': 'The aim of this study was to investigate renal function and immunologic markers among chloralkali workers with long-term low exposure to mercury vapor.
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METHODS ': 'Forty-seven currently exposed workers were compared with reference workers matched for age in a cross-sectional design.
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RESULTS ': 'The mean urinary mercury concentration was 5.9 (range 1.1–16.8) nmol/mmol creatinine (Cr) for the exposed workers and 1.3 (range 0.2–5.0) nmol/mmol Cr for the referents. The chloralkali workers had been exposed for an average of 13.3 (range 2.8–34.5) years. The activity of N-acetyl-β(-D-glucosaminidase in urine (U-NAG) was higher in the exposed workers (mean 0.18 U/mmol Cr versus 0.14 U/mmol Cr, P=0.02). Associations between current urinary mercury, cumulative urinary mercury, and cumulative urinary mercury per year (intensity) and U-NAG, autoantibodies to myeloperoxidase (anti-MPO) and proteinase 3 in serum, respectively, were observed. The activity of U-NAG and anti-MPO was increased in the workers with the highest exposure, as assessed by their mean intensity of exposure. The highest activity of U-NAG was observed in the exposed workers with the lower concentrations of selenium in whole blood.
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CONCLUSIONS ': 'The study indicates an effect of exposure on the kidney proximale tubule cells, possibly modified by individual selenium status, and an effect mediated by neutrophil granulocytes.
", issn = "0355-3140", doi = "10.5271/sjweh.564", url = "https://www.sjweh.fi/show_abstract.php?abstract_id=564", url = "https://doi.org/10.5271/sjweh.564" }