Original article

Scand J Work Environ Health 1989;15(2):154-155    pdf

doi:10.5271/sjweh.1869

Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin.

by Nielsen J, Welinder H, Skerfving S

Work-associated rhinitis and asthma occurred in a subject exposed to methyl tetrahydrophthalic anhydride (MTHPA) used as a curing agent in an epoxy resin system. He displayed bronchial hyperreactivity in provocation with methacholine, as well as skin prick test positivity and specific immunoglobulin E (IgE) serum antibodies, against a conjugate of MTHPA and human serum albumin. Thus, it seems likely that the disease was caused by an IgE-mediated allergy.