Proceedings paper

Scand J Work Environ Health 1995;21 suppl 2:5-8    pdf

Mineralogical characteristics of silica polymorphs in relation to their biological activities

by Guthrie GD Jr, Heaney PJ

Numerous aspects of silica polymorphs can affect their biological activities, including periodic structures, compositional variations, dissolution characteristics, surface properties, and particle size and shape. For an understanding of mineral-induced pathogenesis from a mechanistic perspective, the links between these properties and biochemical processes must be elucidated. This paper presents some strategies for designing assays to evaluate these properties.