Original article

Scand J Work Environ Health 1981;7(3):233-236    pdf


Disappearance of carbon monoxide from the blood – comparison of the one-exponential and two-exponential elimination models for rat

by Kurppa K

The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.